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Rare Medication

Medicine profile

Methotrexate

Antimetabolite therapy used in oncology and, in other settings, under distinct protocols and monitoring.

In shortageFDA drug shortage database - checked 20 Sept 2026Shortage page

What this medicine is commonly used for

Commonly requested where oncology or specialty protocols require methotrexate formulations consistent with local labeling.

Informational only. Treatment decisions belong to qualified clinicians and to local labeling.

Shortage and sourcing context

Methotrexate shortages have affected tablets and injectable presentations at different times. Substitution decisions are clinical and regulatory.

How it is presented

Examples of presentations referenced for this medicine. Actual market presentations vary by country and registration, so check the pack in front of you.

  • Tablet
  • Injection

Strength examples 2.5 mg, 25 mg/mL (examples)

Who typically asks us about this medicine

  • Patients and families who cannot fill a prescription locally
  • Hospital pharmacies managing formulary access during a shortage
  • Clinics with defined treatment pathways and continuity of care
  • Procurement teams coordinating licensed cross-border sourcing

Frequently asked questions

Full reference text(expand)

Antimetabolite therapy used in oncology and, in other settings, under distinct protocols and monitoring.

What this medicine is commonly associated with

Commonly requested where oncology or specialty protocols require methotrexate formulations consistent with local labeling.

Shortage and sourcing context

Methotrexate shortages have affected tablets and injectable presentations at different times. Substitution decisions are clinical and regulatory.

Procurement readers and documentation

Teams may attach formulary references, expected delivery windows, and importer details when permitted. This does not change clinical responsibilities.

Presentation examples

Dosage forms referenced on this page may include: Tablet, Injection. Strength examples may include: 2.5 mg, 25 mg/mL (examples). Actual market presentations vary by region and registration.

Important: This page is informational and not a substitute for professional medical advice, local labeling, or institutional protocols.